Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection
Identifieur interne : 001056 ( Main/Exploration ); précédent : 001055; suivant : 001057Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection
Auteurs : Katherine V. Houser ; Lisa Gretebeck ; Tianlei Ying [République populaire de Chine] ; Yanping Wang [États-Unis] ; Leatrice Vogel ; Elaine W. Lamirande ; Kevin W. Bock ; Ian N. Moore ; Dimiter S. Dimitrov [États-Unis] ; Kanta SubbaraoSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2016.
Descripteurs français
- KwdFr :
- ARN viral (analyse), Administration par voie intraveineuse, Administration par voie nasale, Animaux, Anticorps antiviraux (sang), Anticorps antiviraux (usage thérapeutique), Anticorps monoclonaux humanisés (usage thérapeutique), Anticorps neutralisants (sang), Anticorps neutralisants (usage thérapeutique), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Femelle, Humains, Immunoglobulines par voie veineuse, Infections à coronavirus (), Infections à coronavirus (immunologie), Lapins, Modèles animaux de maladie humaine, Poumon (virologie).
- MESH :
- analyse : ARN viral.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Infections à coronavirus.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- usage thérapeutique : Anticorps antiviraux, Anticorps monoclonaux humanisés, Anticorps neutralisants.
- virologie : Poumon.
- Administration par voie intraveineuse, Administration par voie nasale, Animaux, Femelle, Humains, Immunoglobulines par voie veineuse, Infections à coronavirus, Lapins, Modèles animaux de maladie humaine.
English descriptors
- KwdEn :
- Administration, Intranasal, Administration, Intravenous, Animals, Antibodies, Monoclonal, Humanized (therapeutic use), Antibodies, Neutralizing (blood), Antibodies, Neutralizing (therapeutic use), Antibodies, Viral (blood), Antibodies, Viral (therapeutic use), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Disease Models, Animal, Female, Humans, Immunoglobulins, Intravenous, Lung (virology), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), RNA, Viral (analysis), Rabbits.
- MESH :
- chemical , analysis : RNA, Viral.
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Antibodies, Neutralizing, Antibodies, Viral.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- immunology : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- prevention & control : Coronavirus Infections.
- virology : Lung.
- Administration, Intranasal, Administration, Intravenous, Animals, Disease Models, Animal, Female, Humans, Immunoglobulins, Intravenous, Rabbits.
Abstract
With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has high neutralizing activity against MERS-CoV in vitro. m336 was administered to rabbits intravenously or intranasally before infection with MERS-CoV. Prophylaxis with m336 resulted in a reduction of pulmonary viral RNA titers by 40–9000-fold, compared with an irrelevant control antibody with little to no inflammation or viral antigen detected. This protection in rabbits supports further clinical development of m336.
Url:
DOI: 10.1093/infdis/jiw080
PubMed: 26941283
PubMed Central: 4837915
Affiliations:
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Le document en format XML
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Houser</name><affiliation><nlm:aff id="af1"><addr-line>Laboratory of Infectious Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gretebeck, Lisa" sort="Gretebeck, Lisa" uniqKey="Gretebeck L" first="Lisa" last="Gretebeck">Lisa Gretebeck</name><affiliation><nlm:aff id="af1"><addr-line>Laboratory of Infectious Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ying, Tianlei" sort="Ying, Tianlei" uniqKey="Ying T" first="Tianlei" last="Ying">Tianlei Ying</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Key Laboratory of Medical Molecular Virology of Ministries of Education and Health</addr-line>,<institution>Shanghai Medical College, Fudan University</institution>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Yanping" sort="Wang, Yanping" uniqKey="Wang Y" first="Yanping" last="Wang">Yanping Wang</name><affiliation wicri:level="2"><nlm:aff id="af3"><addr-line>Protein Interactions Section, Cancer and Inflammation Program</addr-line>,<institution>Center for Cancer Research, National Cancer Institute, NIH</institution>,<addr-line>Frederick, Maryland</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Frederick</wicri:cityArea></affiliation></author><author><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name><affiliation><nlm:aff id="af1"><addr-line>Laboratory of Infectious Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name><affiliation><nlm:aff id="af1"><addr-line>Laboratory of Infectious Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bock, Kevin W" sort="Bock, Kevin W" uniqKey="Bock K" first="Kevin W." last="Bock">Kevin W. Bock</name><affiliation><nlm:aff id="af2"><addr-line>Comparative Medicine Branch, Infectious Disease Pathogenesis Section</addr-line>,<institution>National Institute of Allergy and Infectious Disease, National Institutes of Health (NIH)</institution>,<addr-line>Bethesda</addr-line></nlm:aff></affiliation></author><author><name sortKey="Moore, Ian N" sort="Moore, Ian N" uniqKey="Moore I" first="Ian N." last="Moore">Ian N. Moore</name><affiliation><nlm:aff id="af2"><addr-line>Comparative Medicine Branch, Infectious Disease Pathogenesis Section</addr-line>,<institution>National Institute of Allergy and Infectious Disease, National Institutes of Health (NIH)</institution>,<addr-line>Bethesda</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dimitrov, Dimiter S" sort="Dimitrov, Dimiter S" uniqKey="Dimitrov D" first="Dimiter S." last="Dimitrov">Dimiter S. Dimitrov</name><affiliation wicri:level="2"><nlm:aff id="af3"><addr-line>Protein Interactions Section, Cancer and Inflammation Program</addr-line>,<institution>Center for Cancer Research, National Cancer Institute, NIH</institution>,<addr-line>Frederick, Maryland</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Frederick</wicri:cityArea></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation><nlm:aff id="af1"><addr-line>Laboratory of Infectious Diseases</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Intranasal</term><term>Administration, Intravenous</term><term>Animals</term><term>Antibodies, Monoclonal, Humanized (therapeutic use)</term><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Neutralizing (therapeutic use)</term><term>Antibodies, Viral (blood)</term><term>Antibodies, Viral (therapeutic use)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (prevention & control)</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Immunoglobulins, Intravenous</term><term>Lung (virology)</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>RNA, Viral (analysis)</term><term>Rabbits</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>Administration par voie intraveineuse</term><term>Administration par voie nasale</term><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Anticorps antiviraux (usage thérapeutique)</term><term>Anticorps monoclonaux humanisés (usage thérapeutique)</term><term>Anticorps neutralisants (sang)</term><term>Anticorps neutralisants (usage thérapeutique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Femelle</term><term>Humains</term><term>Immunoglobulines par voie veineuse</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (immunologie)</term><term>Lapins</term><term>Modèles animaux de maladie humaine</term><term>Poumon (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps monoclonaux humanisés</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Administration, Intravenous</term><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Immunoglobulins, Intravenous</term><term>Rabbits</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie intraveineuse</term><term>Administration par voie nasale</term><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Immunoglobulines par voie veineuse</term><term>Infections à coronavirus</term><term>Lapins</term><term>Modèles animaux de maladie humaine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has high neutralizing activity against MERS-CoV in vitro. m336 was administered to rabbits intravenously or intranasally before infection with MERS-CoV. Prophylaxis with m336 resulted in a reduction of pulmonary viral RNA titers by 40–9000-fold, compared with an irrelevant control antibody with little to no inflammation or viral antigen detected. This protection in rabbits supports further clinical development of m336.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saad, M" uniqKey="Saad M">M Saad</name></author><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name></author><author><name sortKey="Baig, K" uniqKey="Baig K">K Baig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A McGeer</name></author><author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Abdallat, Mm" uniqKey="Al Abdallat M">MM Al-Abdallat</name></author><author><name sortKey="Payne, Dc" uniqKey="Payne D">DC Payne</name></author><author><name sortKey="Alqasrawi, S" uniqKey="Alqasrawi S">S Alqasrawi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name></author><author><name sortKey="Provacia, Lb" uniqKey="Provacia L">LB Provacia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pascal, Ke" uniqKey="Pascal K">KE Pascal</name></author><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name></author><author><name sortKey="Mujica, Ao" uniqKey="Mujica A">AO Mujica</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Ju, Tw" uniqKey="Ju T">TW Ju</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reed, Lj" uniqKey="Reed L">LJ Reed</name></author><author><name sortKey="Muench, H" uniqKey="Muench H">H Muench</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Whitaker, B" uniqKey="Whitaker B">B Whitaker</name></author><author><name sortKey="Sakthivel, Sk" uniqKey="Sakthivel S">SK Sakthivel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marasco, Wa" uniqKey="Marasco W">WA Marasco</name></author><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z Zhu</name></author><author><name sortKey="Chakraborti, S" uniqKey="Chakraborti S">S Chakraborti</name></author><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leyva Grado, Vh" uniqKey="Leyva Grado V">VH Leyva-Grado</name></author><author><name sortKey="Tan, Gs" uniqKey="Tan G">GS Tan</name></author><author><name sortKey="Leon, Pe" uniqKey="Leon P">PE Leon</name></author><author><name sortKey="Yondola, M" uniqKey="Yondola M">M Yondola</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Bock, Kevin W" sort="Bock, Kevin W" uniqKey="Bock K" first="Kevin W." last="Bock">Kevin W. Bock</name><name sortKey="Gretebeck, Lisa" sort="Gretebeck, Lisa" uniqKey="Gretebeck L" first="Lisa" last="Gretebeck">Lisa Gretebeck</name><name sortKey="Houser, Katherine V" sort="Houser, Katherine V" uniqKey="Houser K" first="Katherine V." last="Houser">Katherine V. Houser</name><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name><name sortKey="Moore, Ian N" sort="Moore, Ian N" uniqKey="Moore I" first="Ian N." last="Moore">Ian N. Moore</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Ying, Tianlei" sort="Ying, Tianlei" uniqKey="Ying T" first="Tianlei" last="Ying">Tianlei Ying</name></noRegion></country><country name="États-Unis"><region name="Maryland"><name sortKey="Wang, Yanping" sort="Wang, Yanping" uniqKey="Wang Y" first="Yanping" last="Wang">Yanping Wang</name></region><name sortKey="Dimitrov, Dimiter S" sort="Dimitrov, Dimiter S" uniqKey="Dimitrov D" first="Dimiter S." last="Dimitrov">Dimiter S. Dimitrov</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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}}
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26941283" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |